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- W2374223564 abstract "Objective To investigate the expression of PINCH protein and COX-2 protein in the endometrial cancer.Methods PINCH protein and COX-2 protein were detected in 23 cases of normal endometria,18 cases of atypical hyperplasia and 50 cases of endometrial cancer by immunohistochemistry ABC method.Results The positive expression of PINCH protein in normal endometria,atypical hyperplasia,endometrial cancer were 17.4%,38.8% and 72.0%respectively.The expression was increased gradually.There existed significant differences between them (P0.05).The positive expression of COX-2 protein in normal endometria,atypical hyperplasia,endometrial cancer were 26.1%,61.1%and 80.0%respectively,The expression was increased gradually.There existed signi ficant differences between them(P0.05).The positive expression of PINCH and COX-2 protein had no significant correlation with endometrial cancer staging,metastasis of lymph node,histology type,pathology grade(P0.05). There were positive correlation between the expression of PINCH protein and COX-2 protein(r=0.468,P0.05) Conclusion There are positive correlation between PINCH and COX-2 in development of endometrial cancer.There are close correlation between their expression and they may be as alternative choice as the target for tumor gene therapy." @default.
- W2374223564 created "2016-06-24" @default.
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- W2374223564 date "2010-01-01" @default.
- W2374223564 modified "2023-09-29" @default.
- W2374223564 title "The expression and clinical significance of PINCH and COX-2 protein in the endometrial cancer" @default.
- W2374223564 hasPublicationYear "2010" @default.
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