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- W2374231036 abstract "ObjectiveTo investigate the expression of FasL on trophoblast and Fas on lymphocyte of recurrent spontaneous abortion (RSA) and normal pregnant woman. MethodsImmunohistochemistry was applied to investigate the expression of FasL of RSA and normal early pregnant woman. Flow cytometric analysis was used to examine the expression of Fas on lymphocyte. ResultsThe staining for FasL was detected mainly in cytomembrane or cytoplasma of cytotrophoblast cells and syncytotrophoblast. The localization of FasL of two groups was similar. Staining for FasL of RSA group was less pronounced than in that of normal group. The PU of staining for FasL in RSA group (PU = 13.59±3.73) was lower compared with normal group (PU = 18.03±4.69) (P 0.01). The percentage of CD8+CD95+T lymphocyte and CD95+NK cell was significantly higher in RSA group compared with normal group. However the percentage of CD4+CD95+T lymphocyte did not differ in two groups.ConclusionFasL expression on trophoblast of RSA decreased significantly comparing with that of normal control group. The percentage of CD95+CD8+T lymphocyte and CD95+NK cell in RSA group was higher compared with normal group. It seems that the CD8+T lymphocyte and NK cell were activated abnormally. Fas/FasL may play an important role in the etiology of RSA." @default.
- W2374231036 created "2016-06-24" @default.
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- W2374231036 date "2004-01-01" @default.
- W2374231036 modified "2023-09-25" @default.
- W2374231036 title "Expression of Fas/FasL in Unexplained Recurrent Spontaneous Abortion" @default.
- W2374231036 hasPublicationYear "2004" @default.
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