Matches in SemOpenAlex for { <https://semopenalex.org/work/W2374255281> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2374255281 endingPage "51" @default.
- W2374255281 startingPage "448" @default.
- W2374255281 abstract "To investigate the effect of N-acetyl-cysteine (NAC) and depakine (DP) on the changes of membrane potential and peroxidate in rat cortex neurons exposed to ferrous chloride (FeCl(2)).Cultured cortex neurons of newly born SD rats were randomly divided into control group (PBS group), model group (FeCl(2) group), NAC pretreatment group (NAC group), DP pretreatment group (DP group) and NAC+DP pretreatment group (NAC+DP group). In the latter three groups, NAC (0.08 mg/ml) and DP (0.1 mg/ml) were added in the cell culture 2 and 3 h before FeCl(2) (1 mmol/L) exposure, respectively. After exposure to FeCl(2), the membrane potential of the neurons was detected with fluorescent dye DiBAC4(3) (bis-(1,3-dibutylbarbituric acid) trimethine oxonol), and the peroxidate level with 2,7-dichlorofluorescin diacetate (H(2)DCF) by laser confocal scanning microscope (LCSM) and nuclear factor-KappaB (NF-KappaB) level with immunocytochemistry.Compared with FeCl(2) group, the expression of NF-KappaB and peroxidate level in the neurons were decreased significantly in NAC and NAC+DP groups (P<0.01), but not in DP group (P>0.05). FeCl(2) depolarized the membrane potential and increased the expression of NF-KappaB in the neurons. Compared with FeCl(2) group, significant changes in the membrane potential were observed in DP and NAC+DP groups (P<0.01) but not in NAC or PBS group (P>0.05).Both NAC and DP can protect the neurons from FeCl(2)-induced damage but through different pathways, and their combined use can significantly alleviate neuronal damages due to FeCl(2) exposure. Antioxidants such as NAC in combination with antiepileptic drugs may produce favorable effect in prevention and treatment of posttraumatic epilepsy." @default.
- W2374255281 created "2016-06-24" @default.
- W2374255281 creator A5000513695 @default.
- W2374255281 creator A5017914419 @default.
- W2374255281 creator A5032868649 @default.
- W2374255281 creator A5042125237 @default.
- W2374255281 creator A5048893081 @default.
- W2374255281 creator A5078580577 @default.
- W2374255281 creator A5084079447 @default.
- W2374255281 creator A5084892289 @default.
- W2374255281 date "2006-04-01" @default.
- W2374255281 modified "2023-09-26" @default.
- W2374255281 title "[Effect of N-acetyl-cysteine and depakine pretreatment on ferrous chloride-induced membrane potential and peroxidate changes in rat cortex neurons]." @default.
- W2374255281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16624749" @default.
- W2374255281 hasPublicationYear "2006" @default.
- W2374255281 type Work @default.
- W2374255281 sameAs 2374255281 @default.
- W2374255281 citedByCount "0" @default.
- W2374255281 crossrefType "journal-article" @default.
- W2374255281 hasAuthorship W2374255281A5000513695 @default.
- W2374255281 hasAuthorship W2374255281A5017914419 @default.
- W2374255281 hasAuthorship W2374255281A5032868649 @default.
- W2374255281 hasAuthorship W2374255281A5042125237 @default.
- W2374255281 hasAuthorship W2374255281A5048893081 @default.
- W2374255281 hasAuthorship W2374255281A5078580577 @default.
- W2374255281 hasAuthorship W2374255281A5084079447 @default.
- W2374255281 hasAuthorship W2374255281A5084892289 @default.
- W2374255281 hasConcept C134018914 @default.
- W2374255281 hasConcept C153911025 @default.
- W2374255281 hasConcept C169760540 @default.
- W2374255281 hasConcept C178790620 @default.
- W2374255281 hasConcept C181911157 @default.
- W2374255281 hasConcept C185592680 @default.
- W2374255281 hasConcept C2775832776 @default.
- W2374255281 hasConcept C2777348757 @default.
- W2374255281 hasConcept C2777847592 @default.
- W2374255281 hasConcept C2778004101 @default.
- W2374255281 hasConcept C2983650178 @default.
- W2374255281 hasConcept C35866371 @default.
- W2374255281 hasConcept C41625074 @default.
- W2374255281 hasConcept C55493867 @default.
- W2374255281 hasConcept C86803240 @default.
- W2374255281 hasConcept C95444343 @default.
- W2374255281 hasConceptScore W2374255281C134018914 @default.
- W2374255281 hasConceptScore W2374255281C153911025 @default.
- W2374255281 hasConceptScore W2374255281C169760540 @default.
- W2374255281 hasConceptScore W2374255281C178790620 @default.
- W2374255281 hasConceptScore W2374255281C181911157 @default.
- W2374255281 hasConceptScore W2374255281C185592680 @default.
- W2374255281 hasConceptScore W2374255281C2775832776 @default.
- W2374255281 hasConceptScore W2374255281C2777348757 @default.
- W2374255281 hasConceptScore W2374255281C2777847592 @default.
- W2374255281 hasConceptScore W2374255281C2778004101 @default.
- W2374255281 hasConceptScore W2374255281C2983650178 @default.
- W2374255281 hasConceptScore W2374255281C35866371 @default.
- W2374255281 hasConceptScore W2374255281C41625074 @default.
- W2374255281 hasConceptScore W2374255281C55493867 @default.
- W2374255281 hasConceptScore W2374255281C86803240 @default.
- W2374255281 hasConceptScore W2374255281C95444343 @default.
- W2374255281 hasIssue "4" @default.
- W2374255281 hasLocation W23742552811 @default.
- W2374255281 hasOpenAccess W2374255281 @default.
- W2374255281 hasPrimaryLocation W23742552811 @default.
- W2374255281 hasRelatedWork W2007327553 @default.
- W2374255281 hasRelatedWork W2113795277 @default.
- W2374255281 hasRelatedWork W2213780929 @default.
- W2374255281 hasRelatedWork W2338748116 @default.
- W2374255281 hasRelatedWork W2402126984 @default.
- W2374255281 hasRelatedWork W2409854738 @default.
- W2374255281 hasRelatedWork W2468483348 @default.
- W2374255281 hasRelatedWork W2588976752 @default.
- W2374255281 hasRelatedWork W2994286884 @default.
- W2374255281 hasRelatedWork W3029417122 @default.
- W2374255281 hasRelatedWork W3029449855 @default.
- W2374255281 hasRelatedWork W3029480709 @default.
- W2374255281 hasRelatedWork W3031116388 @default.
- W2374255281 hasRelatedWork W3031254154 @default.
- W2374255281 hasRelatedWork W3031817131 @default.
- W2374255281 hasRelatedWork W3031927425 @default.
- W2374255281 hasRelatedWork W3032336838 @default.
- W2374255281 hasRelatedWork W3032424131 @default.
- W2374255281 hasRelatedWork W3032763060 @default.
- W2374255281 hasRelatedWork W3029251831 @default.
- W2374255281 hasVolume "26" @default.
- W2374255281 isParatext "false" @default.
- W2374255281 isRetracted "false" @default.
- W2374255281 magId "2374255281" @default.
- W2374255281 workType "article" @default.