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- W2374276943 abstract "Objective: To survey the incidence and genotype of α-thalassemia and serum levels of ferritin,vitamin B12,and folic acid in pregnant women of Li nationality in Hainan province.Methods: A total of 239 whole blood and serum samples were obtained from pregnant women of Li nationality in Baoting,Qiongzhong,Wuzhishan,and Lingshui areas,automatic hemocyte analyzer was used to detect related parameters of hemocytes,chemiluminescence immunoassay analyzer was used to detect serum levels of ferritin,vitamin B12,and folic acid,GAP-PCR was used to detect 3 common gene deletions of α-thalassemia.Results: The incidence of α-thalassemia in pregnant women of Li nationality in Hainan province was 63.18%,and the incidences in Baoting,Qiongzhong,Wuzhishan,and Lingshui areas were 63.26%,46.97%,61.36%,and 77.50% respectively,the main types were silent type and standard type.The incidence of ferritin deficiency was 54.81%,the incidences in Baoting,Qiongzhong,Wuzhishan,and Lingshui areas were 46.94%,54.55%,54.55%,and 60.00%,respectively;among the cases with α-thalassemia,the incidences of iron deficiency,vitamin B12 deficiency,folic acid deficiency,and vitamin B12 deficiency combined with folic acid deficiency accounted for 35.56%,0.84%,0.42%,and 0.42%,respectively.The incidence of anemia was 32.22%,104 cases(43.51%) were found with microcytic hypochromic anemia,including 31 cases(29.80%) with α-thalassemia;14 cases(13.46%) with simple iron deficiency,51 cases(49.04%) with α-thalassemia combined with iron deficiency,8 cases(7.69%) with other diseases;among the cases with normal hemogram,95.65% of them had silent genotype.Conclusion: The prevalences of α-thalassemia and iron deficiency in pregnant women of Li nationality in Hainan province are very serious,and folic acid deficiency and vitamin B12 deficiency are rare.Prevention and treatment of α-thalassemia and iron deficiency should be enhanced,hemogram can be used as an effective screening method." @default.
- W2374276943 created "2016-06-24" @default.
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- W2374276943 date "2012-01-01" @default.
- W2374276943 modified "2023-09-22" @default.
- W2374276943 title "Analysis on the levels of α - thalassemia,ferritin,vitamin B_(12),and folic acid in pregnant women of Li nationality in Hainan province" @default.
- W2374276943 hasPublicationYear "2012" @default.
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