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- W2374278465 abstract "[Objective] Study the of the significance dynamic changes of hepatic oval cells in the course of formation and reduction of rat cirrhosis treated with dimethylnitrosamine.[Methods] Rat cirrhosis models were established with dimethylnitrosamine injection by abdominal cavity,once a day,continuous 3 days a week,4 weeks altogether.On the third day,second week,forth week of injection,and second week and forth week after stopping injection,6 modeling and 3 normal rats were sacrificed respectively for dynamical observation.Ultrastructure of hepatic oval cells were detected by transmission electron microscope,expression of Thy1.1and α-SMA by immunohistochemistry and immuoblot,collocation of AFP,CK19 and Thy1.1 by double immuno confocal laser scan microscopy.[Results]There were dynamic changes of hepatic oval cell and the regulatory factors in the course of formation and reduction of rat cirrhosis treated with dimethylnitrosamine: There was typical cirrhosis in the liver on the forth week after the rats were treated with dimethylnitrosamine,the cirrhosis relieved notably on the second week after stopping dimethylnitrosamine.Collocation of AFP,CK19 and Thy1.1 in the liver: There was notable expression of collocation on the third day of modeling;with the time being,the expression increased,which attached to the peak on the second week after stopping dimethylnitrosamine,more than that on the forth week of modeling(P0.05),which dropped on the forth week after stopping dimethylnitrosamine less than that on the second week after stopping dimethylnitrosamine(P0.01),but still higher than that on the second week of modeling.[Conclusion]There is a great significance in reproduction and oriented differentiation of hepatic oval cell in the course of formation and reduction of rat cirrhosis especially in promoting reconstruction of liver tissue which encounter cirrhosis." @default.
- W2374278465 created "2016-06-24" @default.
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- W2374278465 date "2007-01-01" @default.
- W2374278465 modified "2023-09-24" @default.
- W2374278465 title "Significance of oriented differentiation of hepatic oval cells in course of formation and reduction of rat cirrhosis treated with dimethylnitrosamine" @default.
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