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- W2374285425 abstract "Objective: The present thesis designed an ovariectomized rat model,through the exercise and estrogen replacement therapy,to explore the effects of exercise and estrogen on GSK-3β,P-GSK-3β of lipid metabolism in ovariectomized rats.Methods: The ovariectomized female Sprague Dawley rats,provided exercise and estrogen replacement for a period of 15 weeks,were randomly divided into five groups: Sham,Sham+E,OVX,OVX+E and OVX+E2.The exercise groups would performed 18m/min,gradient of 5 degree,45 min and five days a week;The OVX+E2 group was injected the estrogen according to the weight 25 ug/kg weekly,three times a week.After the experiment,the researchers measured the intra-abdominal fat mass in rats,and measured serum levels of estrogen(E2) by radio-immunitied.The total protein content and adipose tissue GSK-3β and P-GSK-3β protein were determined through BCA and Western blot.Results:1) After 15-week experiment,the body weight in OVX was significantly higher than Sham(P0.05),and after exercise and estrogen replacement therapy it decreased respectively(P0.05).2)After ovariectomized,the intra-abdominal fat OVX rats were the heaviest in all group,and through exercise and estrogen replacement,fat mass were decreased significantly(P0.05).3) The triglyceride content in OVX adipose tissue was significantly higher(P0.05),after exercise and estrogen replacement therapy the triglyceride significantly decreased(P0.05).4) The exercise group P-GSK/GSK protein expression in adipose tissue were significantly higher than quiet group(P0.05).Conclusion: 1) Exercise and estrogen replacement therapy in vitro can certain release the ovariectomized rat intra-abdominal fat accumulation.2) Moderate-intensity exercise can improve the ovariectomized rats estrogen(E2) levels.3) Exercise increase adipose tissue P-GSK-3β/GSK-3β protein expression,but estrogen couldn't influence the P-GSK-3β/GSK-3β protein expression." @default.
- W2374285425 created "2016-06-24" @default.
- W2374285425 creator A5069748637 @default.
- W2374285425 date "2012-01-01" @default.
- W2374285425 modified "2023-09-26" @default.
- W2374285425 title "Effect of Exercise and Estradiol on GSK-3β Expression of Ovariectomized Rat" @default.
- W2374285425 hasPublicationYear "2012" @default.
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