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- W2374295536 abstract "Objective:To investigate the expression and clinic significance of chemokine receptors CCR1and CCR5 in bone marrow mononuclear cells(BMMNC) in patients with multiple myeloma. Methods:CCR1,CCR5 was quantified using reverse transcription polymerase chain reaction(RT-PCR) in BMMNC in 28 patients. Results:46.4% patients with MM had expressed CCR1 and CCR5, 17.86% patients expressed CCR1 and 7.1% patients expressed CCR5 only. The levels of CCR1 and CCR5 in patients with more than 2 sites bone destruction were much higher than those less than 2 sites bone destruction(P0.05). The levels of CCR1 and CCR5 in patients with high-risk were much higher than those with intermediate-risk have no significant difference with those patients with low-risk(P0.05). Conclusion:Most patients with MM expressed CCR1,CCR5, the chemokine receptors CCR1,CCR5 are useful marker in the prediction of patient's bone destruction and out-come of postoperative." @default.
- W2374295536 created "2016-06-24" @default.
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- W2374295536 date "2009-01-01" @default.
- W2374295536 modified "2023-09-23" @default.
- W2374295536 title "The expression and clinic significance of CCR1 and CCR5 in patients with multiple myeloma" @default.
- W2374295536 hasPublicationYear "2009" @default.
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