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- W2374300193 abstract "Objective To investigate the factors influencing the efficiency of mobilization and collection of peripheral hematopoietic stem cells in acute leukemia patients. Methods After mobilization with granulocyte colony stimulating factor(G-CSF) or with combination of G-CSF and chemotheraphy for patients of acute leukemia patients, the peripheral blood hematopoietic stem cells were collected by CS 3000 PLUS blood cell separator. The effect of different diseases, ways of mobilization, age, and sex on the mobilization and collection was analyzed. We did WBC count, morphological classification and CD34+detection about the peripheral blood stem cell and the peripheral blood before collected the stem cells. Results The collection was successful with all cases, with MNC6×108/kg, and CD34+2×106/kg. Compared to AML and ALL, the collected MNC were got no obvious difference. But acute lymphocytic leukemia patients collected more CD34+cells; It had a significant differences(P =0.015). Mobilization of the time point about the number of chemotherapy and acquisition of CD34+cells was negatively correlated(P=0.028). There were certain relation between the Lymphocyte numerical and the MNC, CD34+cells in PBSC. They had positive correlation. Conclusion It can successfully collect peripheral hematopoietic stem cells with different protocol according to different diseases, sex and age. To collected in the amount of CD34+ cells, peripheral blood lymphocytes of quantity has certain prediction significance." @default.
- W2374300193 created "2016-06-24" @default.
- W2374300193 creator A5066562420 @default.
- W2374300193 date "2013-01-01" @default.
- W2374300193 modified "2023-09-23" @default.
- W2374300193 title "Clinical analysis of the factors influencing the mobilization and collection of peripheral hematopoietic stem cells in acute leukemia patients" @default.
- W2374300193 hasPublicationYear "2013" @default.
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