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- W2374332559 abstract "Four hundreds 14-d-old AA male broilers were randomly assigned to one of four treatments to investigate the effect of LPS challenged on endocrine hormone and immune function.On day 16,18 and 20,chicks were given intraperitoneal injection of sterile saline containing LPS respectively.Blood samples were taken at 2,4,8,and 24 h after the third injection,serum levels of cortisone,PGE_2,T_3 and T_4 were determined.Lymphocyte blastogenesis and T lymphocyte population were analysized 1 d after the LPS administration,gene expression of IL-2 and IFN-γ was quantified by RT-PCR technology.Antibody titers to NDV was measured on the 23 and 27-d-old.In chicks receving LPS,the level of cortisone and PGE_2,and the ratio of T_4/T_3 were increased,but the level of T_3 decreased,at 8 h aftes injection,there were no significant difference except cortisone among treatments.Chicks with LPS administration had higher lymphocyte proliferative response to mitogens than those with only receving saline,and the ratio of CD3~+T,CD4~+T was higher,LPS also promoted the mRNA expression of IL-2 and IFN-γ in spleen.Antibody titers to NDV was not affected by LPS administration.These results suggested that LPS challenge induced immunological stress in broilers,which was mainly cell-mediated immune response;the levels of cortisone and T_3,the ratio of T_4/T_3 and gene expression of CKs were all sensitive parameters for evaluating immunological stress;and immunological stress was relative,we can not define the degree of it." @default.
- W2374332559 created "2016-06-24" @default.
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- W2374332559 date "2006-01-01" @default.
- W2374332559 modified "2023-09-28" @default.
- W2374332559 title "Effects of Lipopolysaccharide Challenge on Endocrine Hormone and Immune Function in Broilers" @default.
- W2374332559 hasPublicationYear "2006" @default.
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