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• W2374341301 abstract "OBJECTIVE: To investigate the role of ubiquitin protein ligase RING2 in cell cycle and expression of P53 in human bronchial epithelial cells exposed to benzo[a]pyrene. METHODS:The untreated 16 HBE cellsgroups were used as negative control groups,the DMSO groups were used assolvent control groups,the MOCK groups were used as sequence control groups. 16 HBE cells and 16HBE(si RNA-RING2) cells were exposed to Ba P at different concentrations(1,2,4,8,16,32 μmol/L) for 24 h,and were exposed to Ba P at 16 μmol/L for different time points(1,2, 4,8,12,24 h). Flow cytometry was used to evaluate the cell cycle. The levels of P53 protein were detected by Westernblot. RESULTS:After Ba P treatment,compared with the negative control groups,at each concentration and each time point the proportion of S phase of 16 HBE cells were significantly increased(P0.01). However at each concentration and each time point 16HBE(si RNA-RING2) cells groups the proportion of S phase cells were significantly decreased(P0.01). Covariance analysis shows grouping factors(with or without RNAi) and all concentrations had impact on the proportion of S phase,P values were both less than 0.01. The estimated mean of the proportion of S phase in 16HBE(si RNA-RING2) cell group(17.09%) was significantly lower than that of 16 HBE cell group(31.55%). Grouping factors(with or without RNAi) and the exposure time all have impacted on theproportion of S phase,P values were both less than 0.01. The estimated mean of the proportion of S phase in 16HBE(si RNA-RING2) cell group(13.07%) was significantly lower than that of 16 HBE cell group(28.04%)(P0.05). After Ba P treatment,compared with the negative control group,at each concentration and each time point P53 protein levels at 16 HBE cell groups were significantly increased(P0.05). However,at each concentration and each time point 16HBE(si RNA-RING2) cell groups(except 16 μmol/L Ba P treated 8 h) the levels of P53 protein were significantly decreased(P0.05). Covariance analysis shows grouping factors(with or without RNAi) and all concentration showed impact on the level of P53 protein,P values were 0.026 and 0.028,respectively. The estimate mean of the levels of P53 protein in 16HBE(si RNA-RING2) cell group(0.989) was significantly lower than that of 16 HBE cell group(1.375)(P0.05). Grouping factors(with or without RNAi) and the exposure time both impacted on the level of P53 protein,P values were 0.007 and 0.035,respectively. The estimate mean of the levels of P53 protein in 16HBE(si RNA-RING2) cell group(0.857) was significantly lower than that of 16 HBE cell group(1.541)(P0.05). CONCLUSION:The histone ubiquitination modifications in which RING2 was involved may regulate DNA repair by affecting the expression of P53 and cell cycle S phase changes." @default.
• W2374341301 created "2016-06-24" @default.
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• W2374341301 date "2015-01-01" @default.
• W2374341301 modified "2023-09-24" @default.
• W2374341301 title "Role of ubiquitin protein ligase RING2 in cell cycle and expressions of P53 in human bronchial epithelia cells exposed to benzo[a]pyrene" @default.
• W2374341301 hasPublicationYear "2015" @default.
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