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- W2374351617 abstract "An experimental model in which alkylating agent N methyl N′ nitro N nitroguanidine (MNNG) with low concentration was employed to induce genetic instability of a monkey kidney vero cell line, it was proved that there were changes in the patterns of protein tyrosine residue phosphorylation and the activation of stress activated kinase(JNK/SAPK). Now with the same experimental conditions, it is discovered that the phosphorylation degree increased in p38MAPK and its upstream kinase MKK3/MKK6 and upstream activator SEK1/MKK4 of JNK/SAPK, suggesting that both stress signaling pathways in mitogen activated protein kinase(MAPK) family be served by MNNG to activate cellular stress response and there may be cross talks between different pathways." @default.
- W2374351617 created "2016-06-24" @default.
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- W2374351617 date "2001-01-01" @default.
- W2374351617 modified "2023-09-25" @default.
- W2374351617 title "Low concentration N-methyl-N′-nitro-N-nitroguanidine activates p38MAPK signal transduction pathway" @default.
- W2374351617 hasPublicationYear "2001" @default.
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