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- W2374356507 abstract "Objective:To observe and analyze the effect of diacetyl hexamethylene diamine(CAHB,a differentiation inducer of cancer cells) on electrocardiogram(ECG) changes in patients with myelodysplastic syndrome(MDS).Methods: In a phase I clinical trial,48 patients with MDS received designed single or multiple doses of CAHB infusion.In a phase IIA trial,10 MDS patients were treated with continuous intravenous infusion of CAHB for 2 courses.ECG was monitored before,during and after CAHB treatment.Results: All patients finished the phaseⅠtrial.After CAHB administration,abnormal ECG was observed in totally 9 patients: temporary ventricular premature beats in 1 patient;T wave change in 3 patients;ST-T change in 3 patients;left ventricular hypervoltage in 2 patients.No QT interval or QTc prolongation were observed.In the phase IIA trial,10 patients were totally treated for 18 courses.Changes in ventricle depolarization and repolarization were observed in 2 patients,including U wave occurrence,ST segment depression,and T wave flatness.No symptoms,signs,and any abnormality of laboratory examination were found.The ECG changes recovered after the drug discontinuation.Conclusion: The abnormal ECG changes are correlated to the clinical trial drug CAHB,and can recover after drug discontinuation.No significant changes were detected in any other indexes for heart safety." @default.
- W2374356507 created "2016-06-24" @default.
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- W2374356507 date "2008-01-01" @default.
- W2374356507 modified "2023-09-23" @default.
- W2374356507 title "Effect of diacetyl hexamethylene diamine on electrocardiogram in patients with myelodysplastic syndrome" @default.
- W2374356507 hasPublicationYear "2008" @default.
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