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- W2374358085 abstract "Objective: This study is to explore the time characteristic between the expression of NGF,IL-6 and the astrocyte's activation.Methods: Primary cultured rat astrocytes were divided into three groups: the control group which was cultured with the normal medium,the activation group was cultured with the medium which has 20ng/ml ciliary neurotrophic factor(CNTF) in the normal medium,and the inhibit group was cultured with the medium 30μmol/L Genistein in the normal medium after astrocytes were activitied.The shape and the number of astrocytes were examined by immunofluorescence assay,the expression of glialfibrillary acidic protein(GFAP) and NGF,IL-6 were examined by RT-PCR,the contents of IL-6 and NGF in the supernatant were measured by using ELISA.Results: The activation group compared with that in the control group,the number of astrocytes increased,cell body became larger,processes were longer,and woven into a mesh,astrocytes were activited,the expression of GFAP and NGF,IL-6 increased with time,but the highest expression of NGF was earlier than IL-6,and when Genistein was applied in the activitied astrocytes,theastrocytes'number increased and cell body become smaller,processes werere duced,astrocytes'activation was in hibited,and the expression of GFAP decreased.Conclusions: The expression of NGF and IL-6 increased with time after astrocytes were activated,but the highest expression of NGF was earlier than IL-6.These results suggest that the activitied astrocytes may do good on nervous system at initial stage,and they may be harmful with time.Genistein can inhibit the astrocyte's activation to decrease the expression of NGF and IL-6." @default.
- W2374358085 created "2016-06-24" @default.
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- W2374358085 date "2013-01-01" @default.
- W2374358085 modified "2023-09-25" @default.
- W2374358085 title "The Time Characteristic of the Activity of Astrocytes and the Expression of NGF, IL-6" @default.
- W2374358085 hasPublicationYear "2013" @default.
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