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- W2374359678 abstract "PTEN gene, which is located in chromosome 10q23.3, is the first antioncogene found in recent years that exerts phosphatase-like activties. Its roles in cell cycles depend upon three pathways corporately: focal adhesion kinase(FAK), Phosphoinositide 3 kinase (PIP3) and mitogen activited protein kinase (MAPK). Mice embryonic stem cell with homozygous mutation of PTEN developed malformed embryos and resulted in early embryonic lethality, while those mice with heterozygous PTEN had high incidence of tumorigenesis in various type of tissues during embryonic development. We reviewed the structural and biological characteristics of PTEN, roles in cell cycle and embryonic development and prospected the research on PTEN." @default.
- W2374359678 created "2016-06-24" @default.
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- W2374359678 date "2004-01-01" @default.
- W2374359678 modified "2023-09-25" @default.
- W2374359678 title "Roles of PTEN in embryonic development and cell cycles" @default.
- W2374359678 hasPublicationYear "2004" @default.
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