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- W2374367077 abstract "Objective To systematically review the differences of selenium levels in environment between endemic and normal regions and in patients with Kaschin-Beck disease and health people.Methods Such databases as PubMed,he Cochrane Library(Issue 8,2013),EMbase,ISI Web of Knowledge,CNKI,CBM,VIP and WanFang Data were electronically searched to August 16th,2013 for all observational studies about the diferences of selenium levels in environment(including soil,water,and cereal) between endemic and normal regions,and in patients with Kaschin-Beck disease and health people(including blood,urine,and hair) were included.Meta-analysisi was performed using RevMan 5.2 software.Results Forty-six controlled studies were included.The results of meta-analysis showed that,selenium levels in water(SMD=–0.99,95%CI –1.31 to –0.66),soil(SMD=–1.20,95%CI –1.92 to –0.49),cereal(SMD=–1.94,95%CI –2.63 to –1.26) and corn(SMD=–1.66,95%CI –2.33 to –0.98) in endemic region were lower than those in normal region.he selenium in blood(SMD=–1.03,95%CI –1.54 to –0.53),blood serum(SMD=–0.66,95%CI –1.01 to –0.31),red blood cell(SMD=–2.75,95%CI –4.13 to –1.37),urine(SMD=–0.99,95%CI –1.43 to –0.55) and hair(SMD=–1.67,95%CI –2.14 to –1.20) of Kaschin-Beck disease patients were lower than those in healthy people.he results of subgroup analysis also showed that signiicant diferences were found between patients and healthy people in endemic region.he selenium in blood(SMD=–6.12,95%CI –8.58 to –3.66),blood serum(SMD=–1.02,95%CI –1.34 to –0.69),red blood cell(SMD=–3.37,95%CI –5.38 to –1.35),urine(SMD=–1.94,95%CI –2.54 to –1.34),and hair(SMD –3.49,95%CI –5.32 to –1.66) of healthy people in endemic region were lower than those in normal region.Ater removing the speciic studies on every pooling outcome with high risk of heterogeneity,the results of sensitivity analysis showed that the results were of robustness and the impact due to heterogenicity was fairly low.Conclusion Selenium levels in external environment in endemic region are signiicantly lower than those in normal region,and patients' selenium levels in the body are also signiicantly lower than the healthy in endemic region.he selenium levels of the healthy in endemic region are also signiicantly lower than those of the healthy in normal region.Current evidence indicated that lack of selenium in external environment might be related to Kaschin-Beck disease." @default.
- W2374367077 created "2016-06-24" @default.
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- W2374367077 date "2013-01-01" @default.
- W2374367077 modified "2023-09-24" @default.
- W2374367077 title "Correlation between Selenium and Kaschin-Beck Disease:A Meta-Analysis" @default.
- W2374367077 hasPublicationYear "2013" @default.
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