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- W2374389437 abstract "Objective To observe the effect of arsenic trioxide(As2O3) on synoviocytes' proliferation and cytokines excretion in rheumatoid arthritis(RA).Methods Synoviocytes of RA were cultured in vitro.Different concentrations(0,0.5,2 and 5 μmol/L) of As2O3 were applied in the cultured concentrations.The concentrations of TNF-α and IL-1 were observed 24 hours later.TUNEL and flow cytometry were used to detect the proliferation of synoviocyte.Results Compared with the control group,the concentrations of TNF-α and IL-1 decreased significantly in As2O3 group(P0.05).The effects were more apparent when the concentrations of As2O3 were increased.Cell proliferation were significantly decreased in As2O3 group compared with that in control group after three days(P0.05),and the effect was concentration-dependent.The cell cycles of synoviocyte were significantly different between As2O3 group and the control group(P0.05),and the effects showed concentration-dependent.Conclusions As2O3 enhances the proliferation of synoviocyte but inhibits the expressions of secretion of TNF-α and IL-1." @default.
- W2374389437 created "2016-06-24" @default.
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- W2374389437 date "2008-01-01" @default.
- W2374389437 modified "2023-09-24" @default.
- W2374389437 title "Effect of arsenic trioxide on synoviocyte's proliferation and cytokines excretion of rheumatoid arthritis" @default.
- W2374389437 hasPublicationYear "2008" @default.
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