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- W2374392629 abstract "Objective:To investigate the relationship between the levels of interleukin-2, 3, 6, 8, soluble interleukin -2 receptor (sIL-2R), steel factor(SCF) tumor necrosis factor-α(TNF-α)and interferon-γ (IFN-γ) in serum and bone marrow and hematopoiesis in patients with aplastic anemia(AA) and its implication on clinical outcome. Methods: Using enzyme-linked immunoadsorbent assay(ELISA), have studied pre- and post-treatment serum and bone marrow level of IL-2, IL-2R, IL-3, IL-6, IL-8, SCF, TNF-α and IFN-γ in 37 patients with AA. Results: In compared with controls, the pretreatment levels of IL-2, sIL-2R,IL-3, IL-6, IL-8 , TNF-α and IFN-γ in serum and bone marrow were slightly higher in patients with AA. But the levels of IL-2, IL-8 and IFN-γ were much higher in these patients. The level of SCF was unchanged. Serum and bone marrow IL-3 level were much higher in patients with chronic AA(P0.05), otherwise higher level of IL-2, IL-8, TNF-α and IFN-γ levels was always seen in patients with serious AA(sAA, P0.01). After successful treatment, the levels of cytokines detected in serum and bone marrow tended to return to normal level(P0.05), and decrease of IL-2, IL-8, TNF-α and IFN-γ levels were much more significant(P0.01). Conclusion: The result of the study on AA showed that interdependent role of IL-2, IL-8, TNF-α and IFN-γ on pathogenesis and developing of AA." @default.
- W2374392629 created "2016-06-24" @default.
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- W2374392629 date "2000-01-01" @default.
- W2374392629 modified "2023-09-27" @default.
- W2374392629 title "Evaluation of serum and bone marrow positive- and negative- hematopoietic growth factors in patients with aplastic anemia and its implication on clinical outcome" @default.
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