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- W2374396827 abstract "Objective To investigate the relationship between vacA genotypes of Helicobacter pylori (Hp) and its expression products vacuolating cytotoxin and gastroduodenal diseases. Methods vacA genotypes of 62 Hp strains isolated from patients with chronic gastritis, peptic ulcer and gastric cancer were tested by polymerase chain reaction and Hela cell assay for vacuolating cytotoxin activity in vitro. Results All 62 Hp strains possessed vacA gene and vacA genotypes of all strains were type sla/m2. The total positivity rate of VacA was 37.1%; the positivity rates of VacA produced by Hp strains isolated from patients with chronic gastritis, peptic ulcer and gastric cancer were 33.33%, 29.17% and 63.64%, respectively. There were no significant differences between the positivity rates of VacA produced by Hp strains isolated from patients with the above mentioned diseases ( P 0.05). Conclusions vacA genotypes of Helicobacter pylori and VacA can not predict subjects, infected with Helicobacter pylori who will be more likely to develop CG, PU or GC. The relationship between vacA genotypes of Hp and VacA can not be identified in this study." @default.
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- W2374396827 date "2000-01-01" @default.
- W2374396827 modified "2023-09-23" @default.
- W2374396827 title "A study on correlation between vacA genotypes and its expression products of H pylori, and gastroduodenal diseases" @default.
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