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- W2374400265 abstract "The sirolimus nanostructured lipid carriers was solidified by freeze-drying method with the mixture of microcrystalline cellulose(Avicel PH-101) and polyvinyl pyrrolidone(PVP) K30(4:1,w/w) as the adsorption powder.The preparation was optimized by single factor test with dispersing time,average particle size and distribution, fluidity and leakage rate as the indexes.The results showed that the angle of repose and tap density of three batches of the optimized solidified powder were(42.65±0.80)°and(0.79±0.03) g/ml with good content uniformity.The solidified powder could disperse within(10.0±0.4)min and the average particle size and polydispersity index(PDI) of its redispersing solution were(132.7±2.6)nm and 0.297±0.01 with the(?) potential of(-12.8±1.05)mV.The leakage rate of the products was(10.80±0.41)%." @default.
- W2374400265 created "2016-06-24" @default.
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- W2374400265 date "2012-01-01" @default.
- W2374400265 modified "2023-09-25" @default.
- W2374400265 title "Preparation of Solidification Preparation of Sirolimus Nanostructured Lipid Carriers" @default.
- W2374400265 hasPublicationYear "2012" @default.
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