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- W2374408785 abstract "Objective To study the combined effect of exposure to formaldehyde and toluene on DNA damage in brain of mice.Methods Thirty-six healthy clean-class Kunming mice were randomly divided into nine groups,the control group(0 mg/m3 formaldehyde+0 mg/m3toluene),formaldehyde group(1,5 mg/m3),toluene group(400,2 000 mg/m3),combined group(1 mg/m3 formaldehyde+400 mg/m3toluene,1 mg/m3formaldehyde+2 000 mg/m3toluene,5 mg/m3formaldehyde+400 mg/m3toluene,5 mg/m3 formaldehyde+2 000 mg/m3 toluene).3×3 factorial analysis was used in the experiment.The treatments were conducted by static inhaling formaldehyde or(and) toluene,two hours per day for 14 days consecutively.The DNA damage in brain cells of the mice were detected with comet assay.Results When the mice were jointly exposed to formaldehyde and toluene,the percentage of tail DNA and tail moment in brain cells in exposure groups were higher than the control group(P 0.05).There was an interaction between formaldehyde and toluene on percentage of tail DNA and tail moment(P0.05),and they have synergistic effect.Conclusion Formaldehyde and toluene may induce DNA damage in brain cells of mice.The joint toxicity of formaldehyde and toluene is considered synergistic." @default.
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- W2374408785 date "2012-01-01" @default.
- W2374408785 modified "2023-09-25" @default.
- W2374408785 title "DNA damages in brain cells of mice induced by joint exposure to formaldehyde and toluene" @default.
- W2374408785 hasPublicationYear "2012" @default.
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