Matches in SemOpenAlex for { <https://semopenalex.org/work/W2374409596> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2374409596 abstract "Aim To investigate the effect of inhibiting NF-κB activity on the mRNA expression of TGF-β1 in the diabetic kidneys. Methods The male Wistar rats were divided into: the group A was the normal rats, the group B was the diabetic rats without any treatment, and the group C was the diabetic rats treated with PDTC (an inhibitor of NF-κB activity). The diabetic model was made by the intraperitoneal injection of streptozotocin. After a period of 18 weeks, the kidneys were taken out from all the rats to examine the NF-κB activity by EMSA and the mRNA expression of TGF-β1 by RT-PCR, as well as to observe the glomerular basement membrane (GBM) thickening and mesangial matrix (MM) density(MM area/mesangial area) by electron microscope. Also the 24 h of urine albumin excretion (UAE) was measured. Results The renal NF-κB activity in group B (1.85± 0.54×10 6) was significantly higher than that in the group A (0.07±0.11×10 6, P0.01), and in the group C (0.25±0.25×10 6) lower than in the group B(P0.01). Compared with those in the group A,the UAE (2.18±1.98 mg vs 0.41±0.47 mg, P0.01) ,the GBM thickening (531.6±107.6 nm vs 312.4±25.4 nm, P0.01) and the MM density (56.41±6.78 vs 33.95±5.22, P0.01) were increased significantly in the group B,and all the UAE (0.56 ±0.72 mg),the GBM thickening (315.8±21.4 nm) and the MM density (37.97±7.37) in the group C lower significantly than those in the group B(all were P0.01). The mRNA expression of TGF-β1 in group B(0.53±0.20)was increased significantly when compared with those in the group A(0.26±0.13,P0.01)and in the group C(0.29±0.10,P0.01).Conclusion Inhibiting NF-κB activity can delay the DN and decrease the mRNA expression of TGF-β1 in diabetic kidneys, suggesting that NF-κB may join in the pathogenesis of DN by way of TGF-β1." @default.
- W2374409596 created "2016-06-24" @default.
- W2374409596 creator A5061568119 @default.
- W2374409596 date "2004-01-01" @default.
- W2374409596 modified "2023-09-25" @default.
- W2374409596 title "The effect of inhibiting nuclear factor-κB activity on the mRNA expression of transforming growth factor-β1 in the diabetic kidneys" @default.
- W2374409596 hasPublicationYear "2004" @default.
- W2374409596 type Work @default.
- W2374409596 sameAs 2374409596 @default.
- W2374409596 citedByCount "0" @default.
- W2374409596 crossrefType "journal-article" @default.
- W2374409596 hasAuthorship W2374409596A5061568119 @default.
- W2374409596 hasConcept C10146269 @default.
- W2374409596 hasConcept C104317684 @default.
- W2374409596 hasConcept C105580179 @default.
- W2374409596 hasConcept C118131993 @default.
- W2374409596 hasConcept C126322002 @default.
- W2374409596 hasConcept C134018914 @default.
- W2374409596 hasConcept C185592680 @default.
- W2374409596 hasConcept C2776115139 @default.
- W2374409596 hasConcept C2777785397 @default.
- W2374409596 hasConcept C2779280383 @default.
- W2374409596 hasConcept C2779922275 @default.
- W2374409596 hasConcept C2780091579 @default.
- W2374409596 hasConcept C2780159080 @default.
- W2374409596 hasConcept C2780368995 @default.
- W2374409596 hasConcept C2780678043 @default.
- W2374409596 hasConcept C55493867 @default.
- W2374409596 hasConcept C555293320 @default.
- W2374409596 hasConcept C71924100 @default.
- W2374409596 hasConceptScore W2374409596C10146269 @default.
- W2374409596 hasConceptScore W2374409596C104317684 @default.
- W2374409596 hasConceptScore W2374409596C105580179 @default.
- W2374409596 hasConceptScore W2374409596C118131993 @default.
- W2374409596 hasConceptScore W2374409596C126322002 @default.
- W2374409596 hasConceptScore W2374409596C134018914 @default.
- W2374409596 hasConceptScore W2374409596C185592680 @default.
- W2374409596 hasConceptScore W2374409596C2776115139 @default.
- W2374409596 hasConceptScore W2374409596C2777785397 @default.
- W2374409596 hasConceptScore W2374409596C2779280383 @default.
- W2374409596 hasConceptScore W2374409596C2779922275 @default.
- W2374409596 hasConceptScore W2374409596C2780091579 @default.
- W2374409596 hasConceptScore W2374409596C2780159080 @default.
- W2374409596 hasConceptScore W2374409596C2780368995 @default.
- W2374409596 hasConceptScore W2374409596C2780678043 @default.
- W2374409596 hasConceptScore W2374409596C55493867 @default.
- W2374409596 hasConceptScore W2374409596C555293320 @default.
- W2374409596 hasConceptScore W2374409596C71924100 @default.
- W2374409596 hasLocation W23744095961 @default.
- W2374409596 hasOpenAccess W2374409596 @default.
- W2374409596 hasPrimaryLocation W23744095961 @default.
- W2374409596 hasRelatedWork W2040080433 @default.
- W2374409596 hasRelatedWork W2265165828 @default.
- W2374409596 hasRelatedWork W2283540215 @default.
- W2374409596 hasRelatedWork W2408509668 @default.
- W2374409596 hasRelatedWork W2542511932 @default.
- W2374409596 hasRelatedWork W2599637773 @default.
- W2374409596 hasRelatedWork W2944832619 @default.
- W2374409596 hasRelatedWork W3005211690 @default.
- W2374409596 hasRelatedWork W3005613054 @default.
- W2374409596 hasRelatedWork W3024007030 @default.
- W2374409596 hasRelatedWork W3030307987 @default.
- W2374409596 hasRelatedWork W3030600647 @default.
- W2374409596 hasRelatedWork W3031572395 @default.
- W2374409596 hasRelatedWork W3032266085 @default.
- W2374409596 hasRelatedWork W3107809712 @default.
- W2374409596 hasRelatedWork W3127308144 @default.
- W2374409596 hasRelatedWork W3129508299 @default.
- W2374409596 hasRelatedWork W3145057184 @default.
- W2374409596 hasRelatedWork W3147912901 @default.
- W2374409596 hasRelatedWork W3148105844 @default.
- W2374409596 isParatext "false" @default.
- W2374409596 isRetracted "false" @default.
- W2374409596 magId "2374409596" @default.
- W2374409596 workType "article" @default.