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- W2374414804 abstract "Objective:To investigate the effect and the mechanisms of Tanreqing Injection on acute lung injury(ALI) in rat induced by lipopolysaccharide(LPS).Methods:56 SD rats were randomly divided into 7 groups:the normal control group,the LPS model of 2h,4h,6h group and the Tanreqing Injection of 2h,4h,6h group.LPS(5mgokg-1) was injected into tail vein in LPS model group and Tanreqing Injection group,1mL Tanreqing Injection was injected into another tain veil in Tanreqing Injection group.Rats were killed at corresponding observation time point.The pathological changes of lung were observed,and lung wet/dry ratio(W/D),the ratio of polymorphonuclear neutrophil(PMN%)in bronchoalveolar lavage fluid(BALF),Pulmonary permeability index(LPI) were calculated.In addition,the concentrations of nitric oxide(NO) and malondialdehyde(MDA),the activities of superoxide dismutase(SOD) and the glutathione peroxidase(GSH-Px) in lung tissues were measured by the method of colorimetry.Results:The acute lung injury model was successfully induced by LPS.The pathological changes of lung in LPS model group were significant.PMN%,lung W / D,LPI,MDA and NO of lung tissue were also significantly increased.SOD and GSH-px in lung tissue were significantly decreased.Compared with LPS model group,PMN%,lung W/D,LPI in Tanreqing Injection group were significantly decreased at corresponding observation time point.However,the MDA and the NO of lung tissue were decreased significantly at 4h and 6 h,while the lung tissue SOD,GSH-px activity were significantly increased at 4h and 6h.Conclusion:Tanreqing Injection shows a protective effect on acute lung injury rats induced by LPS at corresponding observation time point and shows an antioxidant ability at 4h and 6h.Therefore,the infects of Tanreqing Injection on LPS-induced ALI in rats is related with its antioxidant capacity and scavenging oxygen free radicals." @default.
- W2374414804 created "2016-06-24" @default.
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- W2374414804 date "2011-01-01" @default.
- W2374414804 modified "2023-09-28" @default.
- W2374414804 title "Protective Effect of Tanreqing Injection on Acute Lung Injury Rats" @default.
- W2374414804 hasPublicationYear "2011" @default.
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