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- W2374417553 abstract "Multicomponents composite nanofibers have been prepared from co-dissolving solutions of polyvinylpyrrolidone K30(PVP K30), sodium dodecyl sulfate(SDS), and ferulic acid(FA) with a weight ratio of 30∶1∶10 in the 75(v/v)% ethanol aqueous solutions using electrospinning process. FESEM observations showed that the nanofibers were in a format of three-dimensional continuous web with smooth surface and homogeneous structure. 94% of the nanofibers falled in a diameter range of 100-300nm. XRD and DSC results suggested that FA and SDS were able to distribute in the PVP K30 fiber matrix on a molecular scale. ATR-FTIR spectra verified that second-order interactions such as hydrogen bonding, electrostatic forces and hydrophobic forces played a fundamental role in the forming of the composite nanofibers. In vitro dissolution and permeation tests illustrated that the composite nanofibers could improve both the dissolution rates and the permeation profiles of FA." @default.
- W2374417553 created "2016-06-24" @default.
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- W2374417553 date "2010-01-01" @default.
- W2374417553 modified "2023-09-24" @default.
- W2374417553 title "Improving effects of electrospun composite nanofibers on the dissolution and permeation of poorly water soluble drugs" @default.
- W2374417553 hasPublicationYear "2010" @default.
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