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- W2374428300 abstract "Objective To investigate role of Fas/FasL-induced apoptosis in the immunopathogen- esis of ankylosing spondylitis (AS).Methods Sixty clinically definited patients with AS and 30 normal controh were recruited.The expression rate of Fas and FasL in T cell subsets of peripheral blood was de- tected by flow cytometry.Results The expression rate of FasL on CD3~+CD4~+,CD3~+CD8~+T cell subsets in peripheral blood was 0.59%,0.93%,2.93% and 4.32% respectively in early and advanced stage of AS,which was significantly higher than in the normal controls (0.48%,1.14%) (P0.05).As com- pared with normal controls (58.25%,59.91%),the expression rate of Fas in CD3~+CD4~+T cell subsets (64.75%) was significantly increased (P0.05),while that of Fas in CD3~+CD8~+T cell subsets (48.64%) was decreased (P0.05) in early stage of AS;in advanced stage of AS,the expression rate of Fas (57.63%,56.32%) had no significant change.Conclusion The expression of Fas and FasL in T cells of peripheral blood was related with progression of AS;T cells apoptosis dysfunction caused by the abnormal expression of Fas and FasL might be one of the important pathogenesis of AS." @default.
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- W2374428300 date "2007-01-01" @default.
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- W2374428300 title "Expression of Fas/FasL in T cell subsets of peripheral blood in patients with ankylosing spondylitis" @default.
- W2374428300 hasPublicationYear "2007" @default.
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