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- W2374429704 abstract "Objective To evaluate the pharmacokinetic behavior of brucine-loaded polylacticacid nano-particles (Bru-PLA-NPs) in rabbits.Methods An HPLC method was developed for determination of Bru in rabbit plasma.The separation of Bru was achieved with a Kromasil C18 column (250 mm×4.6 mm,5 μm).The mobile phase consists of acetonitrile and water (23∶77).To each liter of water,1.01 gram of sodium heptanesulfonate and 1.36 gram of potassium dihydrogen phosphate were added,and then the pH value of the water was adjusted to 2.8 with phosphoric acid.The flow rate was set at 1 mL/min;The detection wavelength was set at 265 nm;The column temperature was kept at 25 ℃.Compartmental pharmacokinetics was used for calculating the parameters using 3p87 software,a practical pharmacokinetic program by Chinese Association of Mathematic Pharmacology (Beijing,China).Results The pharmacokine-tic data of Bru obtained from the single dose iv administration of Bru-PLA-NPs and Bru solution fit three-compartment and two-compartment open models,respectively.Compared with Bru solution after a single dose iv administration,the elimination half-life (t1/2β) and bioavailability of Bru were increased by 6.6 times and 8.7 times,respectively.Conclusion Compared with Bru solution,the pharmacokinetic behavior of Bru changes obviously,following the iv administration of Bru-PLA-NPs in rabbits." @default.
- W2374429704 created "2016-06-24" @default.
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- W2374429704 date "2009-01-01" @default.
- W2374429704 modified "2023-09-25" @default.
- W2374429704 title "In vivo pharmacokinetics of brucine-loaded polylactide nanoparticles in rabbits" @default.
- W2374429704 hasPublicationYear "2009" @default.
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