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- W2374448145 abstract "To observe the effect of catalase on the decrease of Pax6 expression induced by hyperglycemia in NIT-1 cells.【Methods】 NIT-1 cells were divided into four groups: normal glucose concentration without or with catalase(NG,NG+C);high glucose concentration without or with catalase(HG,HG+C).In vitro the cells were cultured in the different medium as mentioned above for 24 hours.Then the cells were used for 2',7'-dichlorodihydrofluorescein diacetate(H2DCF-DA) staining to detect the level of reactive oxygen species(ROS) and evaluate the expression of Pax6 mRNA by RT-PCR.【Results】 The levels of ROS in HG group(1.10±0.24) were higher than those of in NG group(0.95±0.26,P 0.05),but the levels of ROS in HG+C group(0.94±0.26,P 0.05) were lower as compared with HG group.On the contrary,the expression of Pax6 in HG group(0.64±0.09) was lower than in NG group(0.93±0.12,P 0.05).The mRNA level of Pax6 in HG+C group(0.74±0.11,P 0.05) was higher than in HG group without statistical significance.【Conclusion】 The hyperglycemia could induce the increase of ROS and decrease of Pax6 mRNA levels in NIT-1 cells.The antioxidant could partially restore the decline of Pax6 caused by hyperglycemia,but not significant." @default.
- W2374448145 created "2016-06-24" @default.
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- W2374448145 date "2006-01-01" @default.
- W2374448145 modified "2023-09-26" @default.
- W2374448145 title "Effects of Catalase on Decrease of Pax6 Expression Induced by Hyperglycemia" @default.
- W2374448145 hasPublicationYear "2006" @default.
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