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- W2374455219 abstract "OBJECTIVE To investigate the effects of Liuwei Dihuang pill on CYP450 in rats.METHODS After oral administrated isotonic Na chloride,cimetidine,phenobarbital sodium and Liuwei Dihuang pill for every group,the rats were all given phenacetin(as probe drug) by intra-peritoneal injection.Then the blood samples were collected at different time.A developed HPLC method was used to determine the concentrations of the probe drug in rat plasma.And pharmacokinetics parameters were estimated by DAS.RESULTS The t1/2 values of probe drug in groups of isotonic Na chloride,cimetidine,phenobarbital sodium and Liuwei Dihuang pill was(93.5±9.2),(161.7±11.0),(85.4±9.0) and(67.0±6.7) min,respectively.CONCLUSION Liuwei Dihuang pill has certain inductive effect to the rats CYP450." @default.
- W2374455219 created "2016-06-24" @default.
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- W2374455219 date "2008-01-01" @default.
- W2374455219 modified "2023-09-23" @default.
- W2374455219 title "Effects of Liuwei Dihuang pill on liver cytochrome P450 in rats" @default.
- W2374455219 hasPublicationYear "2008" @default.
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