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- W2374458519 abstract "Objective To investigate in vivo MRI detection of axonal transport for tracing optic nerve pathway and cerebral projection as well as effect of MnCl2 concentration in the vitreous body for transsynaptic crossing. Methods Six adult Wistar rats were randomly divided into two groups: group A (n=3) and group B (n=3). 2 μl volume of 0.8 mmol/L and that of 1.6 mmol/L aqueous solution of MnCl2 was injected into the vitreous body of the left eye of group A and group B respectively. MRI studies were performed at 10 h after Mn 2+ administration to observe optic nerve pathway, one week later, 1 mmol/L aqueous solution of MnCl2 was injected into the lateral geniculate nucleus of all six Wistar rats for observing optic radiation cerebral projection. Results Manganese-enhanced normal optic tracts, lateral geniculate nucleus and superior colliculus can be seen perfectly after 10 h of the vitreous body Mn 2+ administration. But there were no enhanced signal in optic cortex at two group. Manganese-enhanced cerebral projection can be seen after 4 h of the lateral geniculate Mn 2+ administration. Conclusion Manganese-enhanced magnetic resonance imaging can show neuroanatomic tract tracing, and result is consistency with rats anatomy atlas. Mn 2+ concentration in the vitreous body have no relation with transsynaptic crossing in the lateral geniculate nucleus." @default.
- W2374458519 created "2016-06-24" @default.
- W2374458519 creator A5048548439 @default.
- W2374458519 date "2006-01-01" @default.
- W2374458519 modified "2023-09-25" @default.
- W2374458519 title "Manganese-enhanced MR imaging for demonstration of optic never pathway and cerebral projection" @default.
- W2374458519 hasPublicationYear "2006" @default.
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