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- W2374461199 abstract "Aim To search the pyrrolizinones derivatives with high anti-inflammatory and analgesic activities and lower side-effect.Methods Combining the result of NO donor research with pyrrolizinone research,some derivatives of 3H-1,2-dihydro-1-pyrrolizinones having NO-releasing function were designed and synthesized.Their chemical structures were confirmed by IR,()~1H-NMR,and MS.The anti-inflammatory and analgesic activities were tested on xylene-induced mouse ear edema and acetic acid-induced mouse writhing.Result and conclusion Fifteen pyrrolizinone derivetives were prepared.None of them has been reported before.The preliminary pharmacological tests show some of them exhibit the anti-inflammatory activities and/or analgesia activities." @default.
- W2374461199 created "2016-06-24" @default.
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- W2374461199 date "2005-01-01" @default.
- W2374461199 modified "2023-09-23" @default.
- W2374461199 title "Synthesis and anti-inflammatory/analgesia activities of pyrrolizinones" @default.
- W2374461199 hasPublicationYear "2005" @default.
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