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- W2374464917 abstract "Objective To reveal the mechanism of CNS involvement with MG on cell level in vitro. Methods The primary cultured neurons were dissociated from cerebral cortex of newborn rats. Immunoreactions between AChRAb and neuronal AChR on neurons were investigated by using immuhistochemical method,the intracellular Ca[2+] ion was measured at the same time. Results The positive immunoreactions and abnormal reactions of calcium ion were found on those used IgG purified from MG patients sera,the negative reactions were found by using IgG from healthy control. Conclusion It is concluded that AChRAb of MG patients may bind to neuronal nAChR on cultured neurons and induce their physiological changes,that may cause CNS dysfuntion in MG." @default.
- W2374464917 created "2016-06-24" @default.
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- W2374464917 date "2005-01-01" @default.
- W2374464917 modified "2023-09-26" @default.
- W2374464917 title "Effect of AChRAb on intracellular calcium of cultured neurons in rats" @default.
- W2374464917 hasPublicationYear "2005" @default.
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