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- W2374467819 abstract "Objective To evaluate the roles of fractional exhaled nitric oxide(FeNO) in the management of bronchial asthma.Methods Twenty-five asthmatic patients without standard medication treatment were recruited.Budesonide(200 μg,bid) was used for twelve weeks to evaluate the changes of FeNO level,pulmonary functions,ACT scores,blood routine tests,total serum IgE and cell counts in induced sputum.At the same time,Twenty-five healthy people were recruited as control group and their FeNO levels were tested.Results After treated with Budesonide,the FeNO levels(volume fraction) of asthmatic patients were significantly lower than those before treatment [(49.98± 25.98) ×10-9 vs.(109.18±65.23)×10-9,P=0.000].Meanwhile,the FeNO levels of asthmatic patients were markedly higher than those of controllers′ before treatment [(109.18±65.23) ×10-9 vs.(12.44±4.31×10-9,P=0.000],and after trented[(49.98±25.98) ×10-9 vs.(12.44±4.31) ×10-9,P=0.000)].After treatment with Budesonide,the FEV1/pred levels [(83.40%±15.74%) vs.(72.45%±7.48%,) P=0.002],the ACT scores [22.88±1.81 vs.14.88±4.21,P=0.000] of asthmatic patients were significantly higher than their pre-treatment levels;the eosinophil percentage(Eos%) counts in blood routine test [(4.33%±1.89%) vs.(5.70%±1.85%),P=0.004],the total serum IgE [(231.35±200.59) ng/mL vs.(284.81±231.12) ng/mL,P=0.004],the Eos% in induced sputum [(6.58%±3.66%) vs.(10.00%±4.75%),P=0.004] were significantly lower than their pre-treatment levels.The FENO levels before treatment were significant negatively correlated with the ACT scores(r=-0.425,P=0.034) and significant positively correlated with the Eos% in induced sputum(r=0.657,P=0.020).Conclusions FeNO level may be a good parameter for the management of eosinophlic airway inflammation.It may bring benefit to evaluate asthma management." @default.
- W2374467819 created "2016-06-24" @default.
- W2374467819 creator A5000830943 @default.
- W2374467819 date "2013-01-01" @default.
- W2374467819 modified "2023-09-28" @default.
- W2374467819 title "Roles of fractional exhaled nitric oxide(FeNO) in the management of bronchial asthma" @default.
- W2374467819 hasPublicationYear "2013" @default.
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