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- W2374476842 abstract "Objective To explore the expression of P-VDGFR mRNA and proteinic level in hippocampus of rabbit with chronic intermittent hypoxia(CIH),and to analyze their clinical significance.Methods Twenty-four male rabbits were divided into blank control group,experimental group,and air mimic control group.Immunohistochemistry was used to examine the expression of hypoxia inducible factor-1alpha(HIF-1alpha)and inducible nitric oxide synthase(NOS-2)in the myocardial cells.Enzyme-linked immunosorbent assay(ELISA)was used to measure the plasma concentration of vascular endothelial growth factor(VEGF)and endothelin-1(ET-1).Results The expression of HIF-1alpha in myocardial cells of experimental group was significantly increased compared with those of air mimic control group(P0.05)and blank control group(P0.05).The expression of HIF-1alpha in myocardial cells of air mimic control group was not significantly different from that of blank control group(P0.05).The plasma concentration of VEGF of experimental group was significantly higher than those of blank control group(P0.05)and air mimic control group(P0.05).While the plasma concentration of ET-1 of experimental group was significantly higher than that of blank control group(P0.05),it was not significantly different from that of air mimic control group(P0.05).There was no statistically significant difference in the expression of NOS-2 in myocardial cells of all groups(P0.05).Conclusions CIH enhances the expression of HIF-1alpha and its target gene products VEGF and ET-1,and therefore affects the cardiovascular system." @default.
- W2374476842 created "2016-06-24" @default.
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- W2374476842 date "2010-01-01" @default.
- W2374476842 modified "2023-09-24" @default.
- W2374476842 title "Expression of P-VEGFR mRNA and Proteinic Level in Hippocampus of Rabbit with Chronic Intermittent Hypoxia" @default.
- W2374476842 hasPublicationYear "2010" @default.
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