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- W2374477904 abstract "Abstract An increasing body of literature is addressing the immuno-modulating functions of miRNAs which include paracrine signaling via exosome-mediated intercellular miRNA. In view of the recent evidence of intake and bioavailability of dietary miRNAs in humans and animals we explored the immuno-modulating capacity of plant derived miRNAs. Here we show that transfection of synthetic miRNAs or native miRNA-enriched fractions obtained from a wide range of plant species and organs modifies dendritic cells ability to respond to inflammatory agents by limiting T cell proliferation and consequently dampening inflammation. This immuno-modulatory effect appears associated with binding of plant miRNA on TLR3 with ensuing impairment of TRIF signaling. Similarly, in vivo , plant small RNAs reduce the onset of severity of Experimental Autoimmune Encephalomyelities by limiting dendritic cell migration and dampening Th1 and Th17 responses in a Treg-independent manner. Our results indicate a potential for therapeutic use of plant miRNAs in the prevention of chronic-inflammation related diseases." @default.
- W2374477904 created "2016-06-24" @default.
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- W2374477904 date "2016-05-11" @default.
- W2374477904 modified "2023-10-15" @default.
- W2374477904 title "Plant microRNAs as novel immunomodulatory agents" @default.
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- W2374477904 doi "https://doi.org/10.1038/srep25761" @default.
- W2374477904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4863160" @default.
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