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- W2374488415 abstract "Objective:To investigate the expressions of Mfn2(mitofusin 2) in non-small-cell lung cancer(NSCLC) tissues and non-cancerous lung tissues,and analyze its relationship with clinicopathological characteristics of lung carcinomas.Methods:The expressions of Mfn2 mRNA and protein in 92 cases of NSCLC tissues and 27 cases of non-cancerous lung tissues were detected by in situ hybridization and immunohistochemical methods.Results:The positive rates of Mfn2 mRNA and protein in pulmonary squamous cell carcinoma were higher than those in adenocarcinoma(83.33% and 89.58% vs 56.82% and 65.91%),respectively.The positive rates of Mfn2 mRNA and protein in NSCLC were higher than those in the non-cancerous lung tissues(25.93% and 29.63%).The difference was statistically significant among the three groups(P0.001 and P0.01).The expressions of Mfn2 mRNA and protein in well-differentiated(93.75% and 100%) and moderately-differentiated NSCLC(91.67% and 91.67%) were higher than those in poor-diffe-rentiated NSCLC(21.43% and 42.86%).The difference was significant(P0.001).The expressions of Mfn2 mRNA and protein had no correlation with the gender,age,tumor size,TNM stage and lymph node metastasis(P0.05).The expression of Mfn2 mRNA was consistent with that of Mfn2 protein in NSCLC.Conclusion:Mfn2 was involved in the initiation and progression of lung cancer,and the expression of Mfn2 was related to the histological types of lung cancer and its differentiation degree." @default.
- W2374488415 created "2016-06-24" @default.
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- W2374488415 date "2009-01-01" @default.
- W2374488415 modified "2023-09-23" @default.
- W2374488415 title "Expression of mitofusin-2 in non-small-cell lung cancer and its clinical significance" @default.
- W2374488415 hasPublicationYear "2009" @default.
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