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- W2374490410 abstract "Objective To study the immunomodulatory effects of simultaneous injection of mes- enchymal stem cells in rats with liver transplant model.Methods Four groups of rats were set up:group A consisting of 15 SD rats,and the remaining three groups(B,C and D)consisting of 15 SD rats and 15 Wistar rats with the former as the recipients and the latter as the donors for liver transplantation.The rats in group A served as sham-operatlon group.The rats in group B received orthotopic liver transplantation. In the group C,the recipient SD rats received simultaneous injection of mesenchymal stem cells of the SD rats with liver transplant model.In the group D,the recipient SD rats received injection of CsA.The blood levels of ALT and TBil were determined and liver pathological changes and changes of Cytokine were observed.Results The blood levels of ALT and TBil were significantly lower,pathological changes milder in the rats receiving infusion of mesenchymal stem cells from recipients in groups C and D group before the liver transplantation than in group B(P0.05).The concentrations of IL-2 and IFN-γ in group C were siginificantly lower than in group B on the 1st and 7th postoperative day.Level of IL-4 and IL-10 in group C was higher than that in group B on the 7th postoperative day.Conclusion Simultaneous injection of mesenchymal stem cells from recipients can decrease graft rejection in the rats after liver transplantation by depressing the expression of Th1 cytokines." @default.
- W2374490410 created "2016-06-24" @default.
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- W2374490410 date "2007-01-01" @default.
- W2374490410 modified "2023-09-26" @default.
- W2374490410 title "Immunomodulatory effects of simultaneous injection of bone marrow mesenchymal stem cells in rats with liver transplant model" @default.
- W2374490410 hasPublicationYear "2007" @default.
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