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- W2374494032 abstract "Objective To study the influence of different antibiotics on the airway microbiota,and provide an appropriate animal model to demonstrate the effect of normal microbiota on the maturing of immune tolerance. Methods Wistar rats were randomly divided into Normal group,Azithromycin group,Cephalosporin group,and Fosfomycin group. 1 week after neonatal Wistar rats inhaled the antibiotics,the animals were sacrificed with intraperitoneal injection of 10% chloral hydrate; nasal lavage fluids were obtained,and the changes of upper airway microbiota were measured by using DGGE. Results The airway microbiota in cephalosporin group reduced significantly compared with that in normal group( P 0. 05),while specific bacterial bands such as Aerococcus viridans,Enterococcus pseudoavium and Enterobacter cloacae increased. Conclusion Antibiotic treatment has a significant influence on the colonization of airway normal microbiota of neonatal rats,and cephalosporin inhalation can build an appropriate model of airway microbiota dysbiosis." @default.
- W2374494032 created "2016-06-24" @default.
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- W2374494032 date "2015-01-01" @default.
- W2374494032 modified "2023-09-26" @default.
- W2374494032 title "Different antibiotic-driven changes in upper airway microbiota colonization in rats" @default.
- W2374494032 hasPublicationYear "2015" @default.
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