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- W2374495004 abstract "Objective:To investigate insulin resistance and the β-cell function in nondiabetic first degree relatives of type 2 diabetes mellitus(FDR) over 5 years follow-up. Methods:Thirty-two patients with non-diabetic first degree relatives of type 2 diabetes(FDR) and 18 healthy controls(NC)were assigned and measuerd body mass index(BMI), waist hip ratio(WHR), blood pressure, serum lipids, serum glucose and fasting insulin(FINS) at baseline. Homeostasis model assessment(HOMA) was applied to assess the status of insulin resistance and β-cell function. Five years later, all subjects were reexamined. Results:HOMA-IR was significantly elevated and HOMA-β was lower in FDR group compared with baseline. During 5 years follow-up, HOMA-IR was not significantly changed between two the groups, but HOMA-β was significantly lower in FDR group than in NC group. Multiple linear regression analysis showed that FBG, FINS,HDL-C were the major risk factors affecting insulin resistance in FDR and the major risk factors affecting β-cell function was FBG and FINS. Conclusion:The nonobese first degree relatives of type 2 diabetes mellitus had insulin resistance and impaired β-cell function at prediabetic stage, and by step, β-cell function may be significantly lower in the period of developing type 2 diabetes mellitus." @default.
- W2374495004 created "2016-06-24" @default.
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- W2374495004 date "2009-01-01" @default.
- W2374495004 modified "2023-10-07" @default.
- W2374495004 title "Study of Insulin Resistance and β-cell Function in First-degree Relatives of Type 2 Diabetes during 5 Years Follow-up" @default.
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