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- W2374499992 abstract "Objective: To explore the possible role of IDH1 gene mutation in the genesis and development of human glioblastoma.Methods: Exon 4 of IDH1 gene was screened through polymerase chain reaction and direct DNA sequencing.Results: IDH1 gene mutations were found in 19 out of 57 specimens,and mutation occurs only in primary glioblastoma and second glioblastoma,as 4 and 15 respectively in each.No pediatric glioblastomas was found.All mutations were heterozygous and point mutation,and can only be found in exon 4 codon 132.Conclusion: Heterozygous point mutation of IDH1 gene may play an important role in the genesis of glioblastoma.Primary and secondary glioblastoma may originate differently.Different mechanisms possibly contribute to adult or child glioblastomas." @default.
- W2374499992 created "2016-06-24" @default.
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- W2374499992 date "2011-01-01" @default.
- W2374499992 modified "2023-09-25" @default.
- W2374499992 title "Role of IDH1 Gene Mutation in the Genesis of Glioblastoma" @default.
- W2374499992 hasPublicationYear "2011" @default.
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