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- W2374502914 abstract "Objective:To evaluate the irritation,toxicity,hypersensitive on animal skin and the pharmacodynamics function of progesterone cream.Methods:To observe acute toxicity and irritation of progesterone cream,which smearing on the alba-New Zealand rabbits with different dosage,the cutaneous hypersensitivity test was performed on the skin of cavia cobaya;detecting progestational activity by proliferation of rabbit endometrium.Results:Progesterone cream had no remarkable toxicity to the intact or damaged skin of rats,and had no irritation to the intact skin of rabbits,but the mild irritation to the damaged skin was observed.progesterone cream had no hypersensitive effects on the intact skin of cavia cobaya.The mephail index in young female rabbits of different dosagegroups were:0,2.88±0.64,2.50±0.53,2.12±0.64,1.38±0.52 respectively.Conclution:It is safe to use progesterone cream which no any toxic reaction,and possess invariable progestational activities." @default.
- W2374502914 created "2016-06-24" @default.
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- W2374502914 date "2008-01-01" @default.
- W2374502914 modified "2023-09-23" @default.
- W2374502914 title "A study on the cutaneous safety and initial pharmacodynamics of progesterone cream" @default.
- W2374502914 hasPublicationYear "2008" @default.
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