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- W2374503600 abstract "Objective To investigate the effects of lipopolysaccharide(LPS) on the expression of hypoxia inducible factor-1α(HIF-1α) and its target gene glucose transpoter-1(GLUT-1)in human monocyte lines THP-1. Methods THP-1 cells were stimulated with 1 μg/mL LPS for 0,2,4,6 or 8 h.The expression of HIF-1α protein of THP-1 cells was detected by Western blotting,and RT-PCR was employed to detect the expression of HIF-1α mRNA and GLUT-1 mRNA.THP-1 cells were exposed to different concentrations of LPS(0,0.01,0.1 and 1 μg/mL) for 6 h,and the expression of HIF-1α protein of THP-1 cells was detected by Western blotting. Results The expression of HIF-1α protein of THP-1 cells began to increase 2 h after being treated with 1μg/mL LPS,significantly increased after exposure for 4 h(P0.05),and reached the peak during 6 to 8 h in the presence of LPS(P0.01).The expression of HIF-1α protein of THP-1 cells was significantly higher than that of control group when being treated with 0.01 μg/mL LPS for 6 h(P0.05),and was even higher when being treated with 0.1 μg/mL or 1 μg/mL LPS for 6 h(P0.01).LPS induced the expression of HIF-1α protein of THP-1 cells in a time and dose-dependent manner.The expression of HIF-1α mRNA and GLUT-1 mRNA was up-regulated in the presence of 1 μg/mL LPS for 2,4,6 and 8 h(P0.01),and increased with time of exposure.Conclusion LPS can promote the expression of HIF-1α and its target gene GLUT-1 in human monocyte lines THP-1 cells." @default.
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- W2374503600 date "2008-01-01" @default.
- W2374503600 modified "2023-09-23" @default.
- W2374503600 title "Effects of lipopolysaccharide on expression of hypoxia inducible factor-1α and its target gene GLUT-1 in human monocyte lines THP-1 cells" @default.
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