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- W2374512921 abstract "Objective To explore the effects of oral intake of glutathione (GSH) with different concentrations on lipid peroxidation in rats Methods After drinking 150 mg/L sodium fluoride (NaF) solution for 10 days,the male Wistar rats were perfused perorally with glutathione at the doses of 60,300 and 600 mg/kg for 12 weeks respectively Meanwhile,the control group drinking distilled water and the exposure group drinking 150 mg/L NaF solution were established among male Wistar rats The activities of superoxide dismutase and the levels of malondialdehyde (MDA) in serum,whole blood,liver,kidney,heart,testis and brain tissue of rats were determined Results Simple exposure to fluoride could result in the significant increases of the levels of MDA in serum,liver,kidney and brain tissue of the rats,as well as the significant decreases of the activities of SOD in whole blood,liver,kidney,heart and testis tissue After the oral perfusion of GSH,the decreases of the levels of MDA were observed in serum,liver,kidney and brain,as well as the significant increases of the activities of SOD in liver,kidney,heart and testis The significant increase of the excretion of fluoride in urine was observed in rats perfused perorally with 300 mg/kg GSH Conclusion Fluoride could promote the lipid peroxidation and deteriorate the anti oxidative capacity,which could be antagonized by oral perfusion of GSH" @default.
- W2374512921 created "2016-06-24" @default.
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- W2374512921 date "2001-01-01" @default.
- W2374512921 modified "2023-09-25" @default.
- W2374512921 title "Effects of Oral Intake of Glutathione on Lipid Peroxidation Induced by Fluoride in Rats" @default.
- W2374512921 hasPublicationYear "2001" @default.
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