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- W2374513643 abstract "Objective:To investigate the Ki-67,MMP-7,MMP-2 expression in cervical intraepithelial neoplasm(CIN)and cervical cancer,with the aim of evaluating their association with the development,aggressiveness and lymph node metastasis.Methods:The immunohistochemical S-P method and image analysis were used to detect Ki-67,MMP-7,MMP-2 expression in 50 cases with cervical cancer,23 cases with CIN and 20 cases of normal control.Results:Ki-67,MMP-7,MMP-2 were mainly expressed in the membrane and /or cytoplasm in tumor cells.The positive rate of Ki-67,MMP-7and MMP-2 were 72.00%,78.00%,76.00%in carcinoma,47.83%, 60.87%,56.52%in CIN lesions,10,0,0 in normal cervical tissues respectively.Expression rate in ICC was obviously higher than that in control group(P0.01).The adencarcinoma(AC)group was higher than squamous cell carcinoma group(SCC)groups(P0.05).No difference was found between CINⅠand CINⅡ-Ⅲin their ki-67 expression(P0.05).High grade diseases and those with lymph node involved presented with higher ki-67 expression than low grade diseases and those without lymph node metastasis(P0.05).Similarly, cervical cancer displayed much higher MMP-7 and MMP-2 expression as compared with CIN and normal controls(P0.01).Pathological features or histological differentiation have no impact upon their expression level.However,those with lymph node involved demonstrated higher MMP-7 and MMP-2 expression than those without.Conclusion:The expression of ki-67,MMP-2 and MMP-7 was associated with the aggressive and metastatic behavior of tumor cells in CIN and invasive cervical cancer." @default.
- W2374513643 created "2016-06-24" @default.
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- W2374513643 date "2010-01-01" @default.
- W2374513643 modified "2023-09-24" @default.
- W2374513643 title "Expression and significance of Ki-67,MMP-2 and MMP-7 in CIN and cervical cancer" @default.
- W2374513643 hasPublicationYear "2010" @default.
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