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- W2374526255 abstract "Some methods have been developed to use CO_2 as the raw material to produce degradable polymeric materials.The terpolymer of carbonate(PPGC) synthesized with the terpolymerization of CO_2,propylene oxide and γ-butyrolactone(GBL).GBL offered an ester structural unit making the copolymer easier to hydrolyze.Hence, PPCG should be of good degradability.In order to study its degradability,the polymer PPCG was used as materials for drag loading.The drug-loaded microspheres were obtained by the W/O/W type emulsions method. The microspheres were spherical in shape with smooth surfaces and good dispersion. The drug loading and encapsulation efficiency were 36.7% and 78.6%, respectively. The degradative behave was studied by SEM, XRD and drug release curves in different degradation medium were obtained.It was found that these microspheres could be degraded at faster speed in the basic media, while could not be degraded in the acidic media.The higher pH value of the medium was,the faster the initial degradative speed was." @default.
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- W2374526255 date "2005-01-01" @default.
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- W2374526255 title "STUDY ON DEGRADABILITY OF MICROSPHERES MADE OF CARBON DIOXIDE/PROPYLENE OXIDE/γ-BUTYROLACTONE COPOLYMER" @default.
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