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- W2374552877 abstract "Objectives To investigate the relation between symptoms/pulmonary function and airway hyperresponsiveness in asthmatic children,and to evaluate the airway inflammatory indices for guiding asthma therapy. Methods Pulmonary function test and bronchial provocation test of inhaling metacholine were performed in 38 asthmatic children before treatment and three months,one year,two years after treatment respectively. PEF、FEV1、MMEF、PC35 sGaw were recorded and analyzed. Results Of all asthmatic children,97.4% with combined ICS + LABA therapy achieved complete control. After two-year-therapy,pulmonary function of 36 patients return to normal. FEV1、MMEF and PEF improved more with the duration of therapy (all P 0.001). There was significant improvement of airway hyperresponsiveness after therapy. However,positive reaction to metacholine challenge test persisted in 57.9% of all asthmatic children after the two-year-therapy,which showed slight airway hyper-reactivity. Conclusions Although achieving complete clinical control,the asthmatic patients still exhibit airway hyperresponsiveness indicating persistent airway inflammation. The parameters related to airway inflammation including PC35 sGaw may be of more value in assessing the efficacy of treatment and adjustment of medication regimens." @default.
- W2374552877 created "2016-06-24" @default.
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- W2374552877 date "2008-01-01" @default.
- W2374552877 modified "2023-09-24" @default.
- W2374552877 title "Significance of bronchial hyperresponsiveness test in the therapy of childhood asthma" @default.
- W2374552877 hasPublicationYear "2008" @default.
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