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- W2374553480 abstract "Objective To study the inhibition effect of ethanol extract toadvenom (EET) on S180 ascites and solid tumors and its toxicity in mice.Methods EET was purified by decompressing distillation, then injected intraperitoneally or subcutaneously into the mice bearing S180 ascites or solid tumors.The inhibition rate of tumor and the prolongation rate of life in mice were calculated and the toxicity of EET was evaluated by biochemical parameters and pathological examination.Results The inhibition rate of EET 5 mg/kg and 0.5 mg/kg in mice bearing S180 solid tumors were 47.0% and 34.1%,respectively (P0.05),and the prolongation rate of life in mice bearing S180 ascites tumors were 46.2% and 36.5%,respectively (P0.05).EET 0.5 mg/kg increased the number of white blood cells to (11±4)×10~9/L (P0.05) and EET 5 mg/kg increased the total bilirubin to (30±5)μmol/L (P0.05).Conclusion These results suggest that EET 0.5～5 mg/kg can inhibit the growth of S180 ascites and solid tumors in vivo in mice, but EET 5 mg/kg may injure the liver." @default.
- W2374553480 created "2016-06-24" @default.
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- W2374553480 date "2006-01-01" @default.
- W2374553480 modified "2023-09-24" @default.
- W2374553480 title "Inhibition effect of ethanol extract of toad venom on S180 ascites and solid tumors and its toxicity in mice" @default.
- W2374553480 hasPublicationYear "2006" @default.
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