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- W2374558282 abstract "Objective To study the systemic and mucosal antibody response induced by intranasal immunization with inactived high pathogenic avian influenza vaccine combined with adjuvant MF59.Methods Inactived high pathogenic avian influenza vaccine formulated with MF59 was administered intranasally.Mouse sera were collected every week after immunization.Changes of serum IgG,IgA,and IgM were observed,as well as the titers of hemagglutination inhibition(HAI) and the specific IgG and sIgA in lung and nasal washes were determined.Results The serum titer of H5N1+MF59 group was higher than that of H5N1 group(P0.01);with the dose increasing,the titer of serum went upwardly.When the dose increased over 12 μg,the titer stopped to decrease.So the dose of 12 μg was the optimal dosage.In addition,the titer of HAI and the specific IgG and IgA in lung and nasal washes was increased significantly in H5N1+MF59 group.The titer of specific secrete IgA was higher than that of specific IgG,while the subtypes of antibody were mostly IgG1 and IgG2b.Conclusion In combination with adjuvant MF59,the inactived H5N1 vaccine might elicit humoral immunoresponse and also induce specific secreting IgA and IgG to neutralize H5N1 virus in mucosal immune response." @default.
- W2374558282 created "2016-06-24" @default.
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- W2374558282 date "2009-01-01" @default.
- W2374558282 modified "2023-09-23" @default.
- W2374558282 title "Immunity response induced by intranasal immunization with inactived human high pathogenic avian influenza vaccine" @default.
- W2374558282 hasPublicationYear "2009" @default.
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