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- W2374560113 abstract "Objective To investigate the mechanisms of age-related macular degeneration ( AMD) with comparative proteomics at the protein expression level.Methods Thirteen wet AMD and 11 dry AMD patients were enrolled in the study,6 healthy volunteers as control.Plasma proteomic analyses of three groups were made using two-dimensional gel electrophoresis,mass spectrography and bioinformatics.Results A total of 219 differential expressed protein spots were detected among three groups.28 spots of them were successfully identified.These proteins were involved in key functional pathways,such as immune response,cytokine,regulation of cell proliferation,damage response,metabolism and antioxidant.After comprehensive analysis of differential proteins among three groups,it was indicated that obvious complement activation,relative high-level expression of cell growth factors,enhancement of cell proliferation and reduced anti-damage function were involved in wet AMD,metabolic disorders and reduced antioxidant function in both dry and wet AMD.Conclusion Changes of plasma protein expression in AMD patients provide a basis for mechanism investigation of AMD,which may prefer the early potential diagnostic and therapeutic strategies for AMD." @default.
- W2374560113 created "2016-06-24" @default.
- W2374560113 creator A5049781553 @default.
- W2374560113 date "2013-01-01" @default.
- W2374560113 modified "2023-09-23" @default.
- W2374560113 title "Preliminary study on plasma proteomic in patients with age-related macular degeneration" @default.
- W2374560113 hasPublicationYear "2013" @default.
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