Matches in SemOpenAlex for { <https://semopenalex.org/work/W2374564213> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2374564213 abstract "Objective To investigate the effects of p73 gene on pathogenesis of adult acute lymphoblastic leukemia ( ALL ) and clinical significance of abnormal expression of p73 gene. MethodsGenomic DNA and total RNA were extracted from 30 ALL and 16 normal bone marrow samples. The expression of p73 was evaluated by RT-PCR. The methylation specific PCR (MSP) was performed to examine the methylation status of p73 gene exon 1.Results Of 30 ALL samples, 21 showed expression of p73 mRNA, with a negative rate of 30%. Normal samples all had expression of p73 gene. All patients without expression of p73 were found to have methylation of p73 gene, whereas only one of patients with expression of p73 mRNA was found to have methylation. Negative expression of p73 gene was associated with higher age (≥60 years old ), higher leucocyte count (≥30×109/L ) and delayed reaction to therapy (patients attained complete remission after 4 weeks ). Conclusion Negative expression of p73 gene probably plays a role in the pathogenesis of adult ALL,and might have clinical significance in predicting its prognosis.Methylation may be the major mechanism of gene silence of p73 in adult ALL." @default.
- W2374564213 created "2016-06-24" @default.
- W2374564213 creator A5076617814 @default.
- W2374564213 date "2008-01-01" @default.
- W2374564213 modified "2023-09-26" @default.
- W2374564213 title "Abnormal expression and significance of p73 gene in adult acute lymphoblastic leukemia" @default.
- W2374564213 hasPublicationYear "2008" @default.
- W2374564213 type Work @default.
- W2374564213 sameAs 2374564213 @default.
- W2374564213 citedByCount "0" @default.
- W2374564213 crossrefType "journal-article" @default.
- W2374564213 hasAuthorship W2374564213A5076617814 @default.
- W2374564213 hasConcept C104317684 @default.
- W2374564213 hasConcept C142724271 @default.
- W2374564213 hasConcept C150194340 @default.
- W2374564213 hasConcept C153911025 @default.
- W2374564213 hasConcept C190727270 @default.
- W2374564213 hasConcept C203014093 @default.
- W2374564213 hasConcept C2778461978 @default.
- W2374564213 hasConcept C2780007613 @default.
- W2374564213 hasConcept C2780942790 @default.
- W2374564213 hasConcept C33288867 @default.
- W2374564213 hasConcept C36823959 @default.
- W2374564213 hasConcept C502942594 @default.
- W2374564213 hasConcept C54355233 @default.
- W2374564213 hasConcept C63363279 @default.
- W2374564213 hasConcept C71924100 @default.
- W2374564213 hasConcept C86803240 @default.
- W2374564213 hasConceptScore W2374564213C104317684 @default.
- W2374564213 hasConceptScore W2374564213C142724271 @default.
- W2374564213 hasConceptScore W2374564213C150194340 @default.
- W2374564213 hasConceptScore W2374564213C153911025 @default.
- W2374564213 hasConceptScore W2374564213C190727270 @default.
- W2374564213 hasConceptScore W2374564213C203014093 @default.
- W2374564213 hasConceptScore W2374564213C2778461978 @default.
- W2374564213 hasConceptScore W2374564213C2780007613 @default.
- W2374564213 hasConceptScore W2374564213C2780942790 @default.
- W2374564213 hasConceptScore W2374564213C33288867 @default.
- W2374564213 hasConceptScore W2374564213C36823959 @default.
- W2374564213 hasConceptScore W2374564213C502942594 @default.
- W2374564213 hasConceptScore W2374564213C54355233 @default.
- W2374564213 hasConceptScore W2374564213C63363279 @default.
- W2374564213 hasConceptScore W2374564213C71924100 @default.
- W2374564213 hasConceptScore W2374564213C86803240 @default.
- W2374564213 hasLocation W23745642131 @default.
- W2374564213 hasOpenAccess W2374564213 @default.
- W2374564213 hasPrimaryLocation W23745642131 @default.
- W2374564213 hasRelatedWork W2062086937 @default.
- W2374564213 hasRelatedWork W2080613123 @default.
- W2374564213 hasRelatedWork W2169228181 @default.
- W2374564213 hasRelatedWork W2203839384 @default.
- W2374564213 hasRelatedWork W2361079356 @default.
- W2374564213 hasRelatedWork W2363332330 @default.
- W2374564213 hasRelatedWork W2364816536 @default.
- W2374564213 hasRelatedWork W2371561569 @default.
- W2374564213 hasRelatedWork W2380212923 @default.
- W2374564213 hasRelatedWork W2381122924 @default.
- W2374564213 hasRelatedWork W2382502902 @default.
- W2374564213 hasRelatedWork W2386472930 @default.
- W2374564213 hasRelatedWork W2388351989 @default.
- W2374564213 hasRelatedWork W2388726595 @default.
- W2374564213 hasRelatedWork W2410129043 @default.
- W2374564213 hasRelatedWork W2417521915 @default.
- W2374564213 hasRelatedWork W2441913745 @default.
- W2374564213 hasRelatedWork W2469117094 @default.
- W2374564213 hasRelatedWork W2992971808 @default.
- W2374564213 hasRelatedWork W3031948478 @default.
- W2374564213 isParatext "false" @default.
- W2374564213 isRetracted "false" @default.
- W2374564213 magId "2374564213" @default.
- W2374564213 workType "article" @default.