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- W2374582080 abstract "Objective To explore the effects of erythropoietin (EPO) on the proliferation and differentiation of neural stem cells and on the cognition function of vascular dementia (VD) rats. MethodsTotally 45 Sprague-Dawlev (SD) rats were randomly and equally divided into the sham control group, the VD group, and the treatment group. The VD rat model was established by performing cerebral ischemia/reperfusion repeatedly and given an intraperitoneal injection sodium nitroprusside. The rats from the treatment group received an introperitoneal injection of EPO after the establish of VD model, and the animals from the others were treated with normal saline. The learning-memory abilities were measured by using computerized shuttle-training case and the proliferation and differentiation of neural stem cells were detected by immunofluorescence staining. ResultsThe active avoidance reaction (AAR) ratio in the VD group was significantly decreased compared with the sham control group (P0.01), but that in the treatment group was higher than the VD group (P0.01) though still lower than the sham group (P0.01). During the 4 weeks we observed, BrdU labeled cells were migrated from the subgranular zone to granule cell layer. In 1 week after the model established, the number of BrdU labeled cells in the VD group was significantly larger than in the sham control group, but lower than that in the treatment group (P0.01). Immunofluorescence staining showed that the number of BrdU and DCX double labeled cells in the treatment group was significantly larger than that in the VD group. In 4 weeks, the number of BrdU labeled cell was decreased in each group, especially in the VD group, and the number of BrdU and NSE double labeled cells in the treatment group was significantly larger than that in the VD group. But the percentage of BrdU-labeled cells co-labeled with DCX/NSE had no significant difference. ConclusionEPO treatment enhances the proliferation of neural stem cells and improves the ability of learning and memory in VD rats,but has no obvious influence on the differentiation of the neural stem cells." @default.
- W2374582080 created "2016-06-24" @default.
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- W2374582080 date "2009-01-01" @default.
- W2374582080 modified "2023-10-03" @default.
- W2374582080 title "Erythropoietin improves proliferation but not differentiation of neural stem cells in vascular dementia rats" @default.
- W2374582080 hasPublicationYear "2009" @default.
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