Matches in SemOpenAlex for { <https://semopenalex.org/work/W2374588126> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2374588126 abstract "Objective To investigate the effects of berberine on vascular endothelial function in type 2diabetic rats and explore the prophylactic and therapeutic significance and pharmacological mechanism of berberine in type 2 diabetic vascular complications.Methods Wistar rats were randomly divided into four groups:diabetic group, control group,diabetic rats treated with berberine(100mg·kg-1)group,and control rats treated with berberine group.The serum fasting blood glucose(FBG),insulin,total cholesterol(TC),triglyceride(TG)and fasting insulin (FINS)levels were tested.Acetylcholine(ACh)-induced endothelium-dependent relaxation and sodium nitroprusside-induced endothelium-independent relaxation were measured in aortas for estimating endothelial function.In addition,the histopathology measurement was performed with hematoxylin and eosin staining. Results Compared with diabetic group,the FBG,TC and TG levels in diabetic rats treated with berberine were significantly decreased,meanwhile the insulin sensitivity index (ISI)was increased.The Ach-induced endothelium-dependent relaxation in the aorta from diabetic rats was significantly improved in berberine treatment group,while sodium nitroprusside(SNP)-induced endothelium-independent relaxation showed no difference among four groups. The histopathological results showed that berberine attenuated the damage of the aortic endothelium in diabetic rats. However there was no difference in these indexes between control group and berberine treated control group. Conclusion Berberine restores diabetic endothelial dysfunction through decreasing the FBS and blood lipid, improving insulin resistant and enhancing NO bioavailability." @default.
- W2374588126 created "2016-06-24" @default.
- W2374588126 creator A5075861619 @default.
- W2374588126 date "2010-01-01" @default.
- W2374588126 modified "2023-09-25" @default.
- W2374588126 title "Effects of berberine on aortic endothelial function and morphous in type 2 diabetic rats" @default.
- W2374588126 hasPublicationYear "2010" @default.
- W2374588126 type Work @default.
- W2374588126 sameAs 2374588126 @default.
- W2374588126 citedByCount "0" @default.
- W2374588126 crossrefType "journal-article" @default.
- W2374588126 hasAuthorship W2374588126A5075861619 @default.
- W2374588126 hasConcept C126322002 @default.
- W2374588126 hasConcept C134018914 @default.
- W2374588126 hasConcept C2776992346 @default.
- W2374588126 hasConcept C2778163477 @default.
- W2374588126 hasConcept C2778913445 @default.
- W2374588126 hasConcept C2779306644 @default.
- W2374588126 hasConcept C2779610285 @default.
- W2374588126 hasConcept C2780116568 @default.
- W2374588126 hasConcept C2780972559 @default.
- W2374588126 hasConcept C519581460 @default.
- W2374588126 hasConcept C555293320 @default.
- W2374588126 hasConcept C71924100 @default.
- W2374588126 hasConcept C98274493 @default.
- W2374588126 hasConceptScore W2374588126C126322002 @default.
- W2374588126 hasConceptScore W2374588126C134018914 @default.
- W2374588126 hasConceptScore W2374588126C2776992346 @default.
- W2374588126 hasConceptScore W2374588126C2778163477 @default.
- W2374588126 hasConceptScore W2374588126C2778913445 @default.
- W2374588126 hasConceptScore W2374588126C2779306644 @default.
- W2374588126 hasConceptScore W2374588126C2779610285 @default.
- W2374588126 hasConceptScore W2374588126C2780116568 @default.
- W2374588126 hasConceptScore W2374588126C2780972559 @default.
- W2374588126 hasConceptScore W2374588126C519581460 @default.
- W2374588126 hasConceptScore W2374588126C555293320 @default.
- W2374588126 hasConceptScore W2374588126C71924100 @default.
- W2374588126 hasConceptScore W2374588126C98274493 @default.
- W2374588126 hasLocation W23745881261 @default.
- W2374588126 hasOpenAccess W2374588126 @default.
- W2374588126 hasPrimaryLocation W23745881261 @default.
- W2374588126 hasRelatedWork W1971454099 @default.
- W2374588126 hasRelatedWork W1988905501 @default.
- W2374588126 hasRelatedWork W2075111858 @default.
- W2374588126 hasRelatedWork W2091830216 @default.
- W2374588126 hasRelatedWork W2106218761 @default.
- W2374588126 hasRelatedWork W2160532649 @default.
- W2374588126 hasRelatedWork W2348266981 @default.
- W2374588126 hasRelatedWork W2354812744 @default.
- W2374588126 hasRelatedWork W2355257613 @default.
- W2374588126 hasRelatedWork W2366736897 @default.
- W2374588126 hasRelatedWork W2370085550 @default.
- W2374588126 hasRelatedWork W2373778099 @default.
- W2374588126 hasRelatedWork W2379087668 @default.
- W2374588126 hasRelatedWork W2381406593 @default.
- W2374588126 hasRelatedWork W2388475384 @default.
- W2374588126 hasRelatedWork W2426910650 @default.
- W2374588126 hasRelatedWork W2959632859 @default.
- W2374588126 hasRelatedWork W2978230633 @default.
- W2374588126 hasRelatedWork W3049218700 @default.
- W2374588126 hasRelatedWork W2746876488 @default.
- W2374588126 isParatext "false" @default.
- W2374588126 isRetracted "false" @default.
- W2374588126 magId "2374588126" @default.
- W2374588126 workType "article" @default.